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I had a problem today that I eventually traced down to the axlbridge.exe from Quickbooks Enterprise 10 (R5). What would happen is that when the user would log in to Quickbooks to open any company file the computer and quickbooks would come to a grinding halt. If you had the patience to close quickbooks through exiting the application the computer would start running fine, but if you killed the process the computer would still run slowly. This helped me indentify the application that was starting with quickbooks causing the issue. I can kill the application and Quickbooks runs fine.

Reinstalling the application, updating the application, or replacing that file did not help. Delete the file and Quickbooks replaces it. I eventually was able to fix the problem by denying permissions for all users of the computer to file. I am not sure what effects that this is going to have, but she is able to use quickbooks for everything that she needs.